Prof. Dr. Elmar Jaenicke


Institut für Molekulare Biophysik
Johannes Gutenberg-Universität
Jakob Welder Weg 26
55128 Mainz
Deutschland

Tel: ++49-(0)6131-3923567
Fax: ++49-(0)6131-3923557
email: elmar.jaenicke@uni-mainz.de

[Werdegang] - [Forschungsinteressen] - [Methoden] - [Lehre] - [Publikationen]

Wissenschaftlicher Werdegang

2010

Außerplanmäßiger Professor

2003 - 2009

Juniorprofessor für Biophysik

2002 - 2003

Wiss. Mitarbeiter am Institut für Molekulare
Biophysik (Uni Mainz)

2002

Promotion (Dr. rer. nat.)

2001

Forschungsaufenthalt an der Rosenstiel
School (University of Miami, USA)

1999 - 2001

Stipendiat des "Fonds der Chemischen
Industrie"

1998

Diplom in Biologie

1991 - 1998

Studium der Biologie und Physik

Forschungsinteressen

Methoden

  • Strukturmethoden (Röntgenstrukturbestimmung, Homologie-Strukturvorhersage, Molekulardynamik)
  • Hydrodynamische Methoden (Analytische Ultrazentrifuge, Statische Lichtstreuung, Dynamische Lichtstreuung)
  • Kalorimetrische Methoden (Isotherme Titrationskalorimetrie, Difreial Scanning Kalorimetrie)
  • Spekroskopische Methoden (Uv/Vis, Floureszenz-, Circular Dichroismus-Spektroskopie)
  • Chromatograpische Proteinreinigung
  • Proteinanalytik (Elektrophoresen, Western-Blot, Immunelektrophorese)

Lehre

Vorlesungen:
Seminare:
Praktika:

Publikationen

  • Jaenicke E, Pairet B, Hartmann H, Decker H (2012): "Crystallization and preliminary analysis of crystals from the 24-meric hemocyanin of emperor scorpion (Pandinus imperator)", PLOS One 7, e32548
  • Jaenicke E, Büchler K, Decker H, Markl J, Schröder GF (2011): "The refined structure of functional unit h of keyhole limpet hemocyanin (KLH1-h) reveals disulfide bridges", IUBMB Life 63, 183-187
  • Pairet B, Jaenicke E (2010): "Structure of the Altitude Adapted Hemoglobin of Guinea Pig in the R2-State", PLoS One 5, e12389
  • Meesters C, Pairet B, Rabenhorst A,DeckerH, Jaenicke E (2010): "Monte Carlo-based rigid body modelling of large protein complexes against small angle scattering data", Comput. Biol. Chem. 34, 158-164
  • Mindykowski B, Jaenicke E, Tenzer S, Cirak S, Schweikardt T, Schild HJ, Decker H (2010): "Cockroach allergens Per a 3 are oligomers", Dev. Comp. Immunol. 34, 722-733
  • Jaenicke E, Büchler K, Markl J, Decker H and Barends T (2010): "The Cupredoxin-like Domains in Hemocyanins", Biochem. J. 426, 373-378
  • Jaenicke E, Fraune S, May S, Irmak P, Augustin R, Decker H, Zimmer M (2009): "Is activated hemocyanin instead of phenoloxidase involved in immune response in woodlice?", Dev. Comp. Immunol. 33, 1055-1063
  • Jaenicke E, Pairet B (2009): "Crystallization of the altitude adapted hemoglobin of guinea pig", Prot. Pept. Lett. 16, 444-446
  • Jaenicke E, Decker H (2008): “Kinetic Properties of Catecholoxidase-Activity of Tarantula Hemocyanin”, FEBS J. 275, 1518-1528
  • Nillius D, Jaenicke E, Decker H (2008): „Switch between tyrosinase and catecholoxidase activity of scorpion hemocyanin by allosteric effectors’, FEBS Lett.582, 749-754
  • Baird S, Kelly SM, Price NC, Jaenicke E, Meesters C, Nillius D, Decker H, Nairn J (2007): “Hemocyanin Conformational Changes Associated with SDS-induced Phenol Oxidase Activation”, Biochim. Biophys. Acta 1774, 1380-94
  • Paoli M, Giomi F, Hellmann N, Jaenicke E, Decker H, Di Muro P, Beltramini M (2007): „The molecular heterogeneity of hemocyanin: structural and functional properties of the 4x6-meric protein of Crustacea”, Gene 398, 177-82
  • Decker H, Schweikardt T, Nillius D, Salzbrunn U, Jaenicke E, Tuczek F (2007): “Similar activation process and catalysis in hemocyanins and tyrosinases”, Gene 398, 183-191
  • Decker H, Hellmann N, Jaenicke E, Lieb B, Meissner U, Markl J (2007): “Recent progress in hemocyanin research“, Integr. Comp. Physiol. 47, 631-644
  • Schweikardt T, Olivares C, Solano F, Jaenicke E, Garcia-Boron J, Decker H (2007): "A three-dimensional model of mammalian tyrosinase active site accounting for loss of function mutants”, Pigment Cell Res. 20, 394-401
  • Mohd Yusof A, Jaenicke E, Pedersen JS, Noegel AA, Schleicher M, Hofmann A (2006): „ Mechanism of Oligomerisation of Cyclase-Associated Protein from Dictyostelium discoideum in Solution”, J. Mol. Biol. 362, 1072-81
  • Rousselot M, Jaenicke E, Lamkemeyer T, Harris JR, Pirow R (2006): “Native and subunit molecular mass and quarternary structure of the haemoglobin from the primitive branchiopod crustacean Triops cancriformis”, FEBS J 273, 4055-4071
  • Lamkemeyer T, Zeis B, Decker H, Jaenicke E, Waschbüsch D, Gebauer W, Markl J, Meissner U, Rousselot M, Thion L, Zal F, Nicholson GJ, Paul RJ (2006): "Molecular mass of macromolecules and subunits and the quarternary structure of hemoglobin from the microcrustacean Daphnia magna", FEBS J. 273, 3393-3410
  • Beltramini M, Colangelo N, Giomi F, Bubacco L, Di Muro P, Hellmann N, Jaenicke E, Decker H (2005): "Quaternary structure and functional properties of Penaeus monodon hemocyanin", FEBS J. 272, 2060-2075
  • Jaenicke E, Decker H (2004): „Conversion of crustacean hemocyanin to catecholoxidase”, Micron 35, 89-90
  • Decker H and Jaenicke E (2004): “Recent findings on phenoloxidase activity and antibacterial activity of hemocyanins”, Dev. Comp. Immunol. 28, 673-687
  • Jaenicke E and Decker H (2004): “Functional changes in the family of type 3 copper proteins in evolution“, ChemBiochem 5, 163-169
  • Hellmann N, Hörnemann J, Jaenicke E, Decker H (2004): „Urate as effector for crustacean hemocyanin“, Micron 35, 109-110
  • Schweikardt T, Jaenicke E, Decker H (2004): „Homology modelling of hemocyanins and tyrosinases: pitfalls in automated approaches“, Micron 35, 97-98
  • Jaenicke E, Walsh P, Decker H (2003): “Isolation and Characterization of Haemoporin, an abundant hemolymph protein of Aplysia californica”, Biochem. J. 375, 681-688
  • Jaenicke E and Decker H. (2003): „Tyrosinase of crustaceans form hexamers“, Biochem. J. 371, 515-523
  • Hellmann N, Jaenicke E, Decker H (2001): „Two types of urate binding sites on hemocyanin from the crayfish Astacus leptodactylus: an ITC study“, Biophys. Chem. 90, 279-299
  • Decker H, Ryan M, Jaenicke E, Terwilliger N (2001): „SDS induced phenoloxidase activity of hemocyanins from Limulus polyphemus, Eurypelma californicum and Cancer magister“, J. Biol. Chem. 276, 17796-17799
  • Jaenicke E, Föll R, Decker H (1999). „Spider Hemocyanin binds Ecdysone and 20-OH-Ecdysone“, J. Biol. Chem. 274, 34267-34271
  • Jaenicke E, Decker H, Gebauer W, Markl J, Burmester T (1999) „Identification, structure, and properties of hemocyanins from diplopod Myriapoda“, J. Biol. Chem. 274, 29071-29074